Volume 7, Issue 3, May 2018, Page: 57-66
Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer
Yuanqing Pan, Department of Medical Psychology, Department of Public Course, Tianjin Medical College, Tianjin, China
Yanxu Yang, Department of Public Health, Tianjin Medical College, Tianjin, China
Yi Dong, Department of Pharmacy, Tianjin Medical College, Tianjin, China
Nan Li, Nursing Department of Neurosurgery, Tianjin Pingjin Hospital, Tianjin, China
Haiqian Liang, Department of Neurosurgery, Tianjin Pingjin Hospital, Tianjin, China
Qi Cui, The Department of Clinical Pathway and Quality Control the Frist Affiliated Hospital of Lanzhou University, Lanzhou, China
Received: May 12, 2018;       Accepted: Jun. 4, 2018;       Published: Jun. 15, 2018
DOI: 10.11648/j.cmr.20180703.12      View  788      Downloads  38
Abstract
Background: In the case of large heterogeneity, the data combination of randomized controlled trials will lead to the decrease of the reliability of systematic review and meta analysis, so we conducted the present study. Objectives: To explore sources of heterogeneity in studies on Tai Chi Chuan (TCC) as a complementary and alternative method for managing the overall quality of life of postoperative breast cancer patients. Methods: Randomized controlled trials were searched for in PubMed, EMBASE, Web of Science and the Cochrane Library through August 2017. The Cochrane Handbook 5.2 standards and Stata software version 10.0 were adopted for evaluating the quality of the included studies and the data was analyzed on overall quality of life of TCC. A separate univariate meta-regression analysis was performed on the study duration, sample size, cancer staging, prior breast cancer treatment, different types of TCC intervention group, different types of control group, intervention duration, mean age, and ethnicity to detect important factors leading to heterogeneity. Results: Significant heterogeneity was present in the included studies that used TCC to improve the overall quality of life of postoperative breast cancer patients from the retrieved literature (P < 0.05). The univariate meta-regression analysis indicated that the source of heterogeneity was not apparent in the analyzed factors within or between studies. Conclusions: A normative approach in studies evaluating the use of TCC for improving the overall quality of life of postoperative breast cancer patients was not sufficiently explored in the existing randomized controlled trials (RCTs). An insufficient number of RCTs in this field may be the reason that the effect size had unclear clinical significance. The existing evidence provided limited judgment on sources of heterogeneity between studies evaluating the use of TCC for improving overall quality of life in postoperative breast cancer patients.
Keywords
Breast Neoplasms, Heterogeneity, Quality of Life, Tai Chi Chuan
To cite this article
Yuanqing Pan, Yanxu Yang, Yi Dong, Nan Li, Haiqian Liang, Qi Cui, Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer, Clinical Medicine Research. Vol. 7, No. 3, 2018, pp. 57-66. doi: 10.11648/j.cmr.20180703.12
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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