Clinical Medicine Research

Volume 8, Issue 1, January 2019

  • Diagnostic Efficacy of Ultrasonography and Fine-needle Aspiration Cytology in Correlation with Histopathology in Euthyroid Patients Having Solitary Thyroid Nodule

    Vijay Kumar Sharma, Antony Abraham Paulose, Parvendra Singh, Nishi Sonkhya

    Issue: Volume 8, Issue 1, January 2019
    Pages: 1-5
    Received: 26 April 2018
    Accepted: 14 May 2018
    Published: 25 February 2019
    Abstract: Objective: In patients with solitary thyroid nodules, first approach is to confirm whether the nodule is benign or malignant. Commonly available investigations used in the evaluation include thyroid hormone assays, fine needle aspiration cytology (FNAC) and ultrasonography (USG) among others. These procedures are not without drawbacks. The present ... Show More
  • The Intervention Threshold for Intracranial Pressure of Traumatic Brain Injury Patients Can Be Determined by Clustering Algorithms and Is Observed to Be 13 mm Hg

    Hermann Prossinger, Hubert Hetz, Alexandra Acimovic, Reinhard Berger, Karim Mostafa, Alexander Grieb, Heinz Steltzer

    Issue: Volume 8, Issue 1, January 2019
    Pages: 6-15
    Received: 21 January 2019
    Accepted: 22 February 2019
    Published: 12 March 2019
    Abstract: During treatment in an intensive care unit (ICU), traumatic brain injury (TBI) patients sometimes suffer an increase in intracranial pressure (ICP). An increase beyond a currently unknown and to-be-determined threshold is very often life-threatening and requires intervention by the clinical staff. Because this threshold value is considered unknown,... Show More
  • Grape Seed Proanthocyanidin Extract Down-Regulates Autophagic Proteins (LC3II and Beclin-1) in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury

    Li Luo, Xing Tu, Wei Liu, Xuexia Zhang, Yilin Liu, Wenyan Zhao, Junhua Yang, Mengxia Wang, Jing Liu

    Issue: Volume 8, Issue 1, January 2019
    Pages: 16-20
    Received: 31 January 2019
    Accepted: 11 March 2019
    Published: 25 March 2019
    Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe brain disease that often leads to death or irreversible sequelae. The aim of this study was to determine the effect of a naturally active drug (grape seed proanthocyanidin extract [GSPE]) on the expression of autophagic proteins in a mouse model of neonatal hypoxic-ischemic brain injury. In... Show More
  • MiR203 Lost Suppressor Genes Function in the Process of Barrett’s Esophagus Carcinogenesis Because of High Methylation in Promoter

    Liu Tianyu, Long Xiaoqi

    Issue: Volume 8, Issue 1, January 2019
    Pages: 21-26
    Received: 13 November 2018
    Accepted: 11 January 2019
    Published: 1 April 2019
    Abstract: This study was designed to explore the role of MiR203 promoter methylation in the process of Barrett’s esophagus carcinogenesis. RT-PCR was used to detect the expression levels of miRNA-203 in Barrett’s esophagus, esophageal cancer and normal esophageal mucosa cell lines, before and after the treatment of demethylation. MiR203 promoter methylation ... Show More
  • Unravelling the Negative Impact of Pain Problems on Recovering from Psychological Trauma

    Carol Valinejad, Steven Lang

    Issue: Volume 8, Issue 1, January 2019
    Pages: 27-31
    Received: 16 October 2018
    Accepted: 9 April 2019
    Published: 9 May 2019
    Abstract: Background: Pain problems can act as a barrier to individuals recovering from psychological trauma following receiving appropriate psychological therapy. Therefore, it would be prudent of therapists to treat pain problems in clients prior to embarking on trauma informed therapy to increase the chances of therapy being more clinically and cost effec... Show More